本會學術會員 Thi-Thuyet Truong (張氏說) 及團隊研究成果獲 The IEEE International Ultrasonics Symposium(IUS2026)2026 國際研討會接受，以壁報（Poster）形式進行現場發表，展現臺灣在治療性超音波領域之研究實力。
本次國際研討會於 2026 年 10 月 4 日至 8 日 美國/北卡羅來納州 舉行，為治療性超音波領域的重要國際學術盛會，匯聚全球專家學者共同交流最新研究成果。
Thi-Thuyet Truong (張氏說) 學術會員及團隊發表之研究題目為 "Focused Ultrasound neuromodulation via Auricular Vagus Nerve Stimulation
Suppresses PTZ-Induced Epileptic Activity in Mice"，為鼓勵會員積極參與國際學術交流、提升臺灣治療性超音波研究能見度，本會提供國際會議壁報發表補助，支持會員將研究成果帶向國際舞臺。
本會謹向Thi-Thuyet Truong (張氏說)學術會員及研究團隊表達誠摯祝賀，期盼未來持續精進研究成果，深化國際學術合作，為治療性超音波之臨床應用與科技發展貢獻更多力量。
Abstract Title: Focused ultrasound neuromodulation via auricular vagus nerve stimulation suppresses PTZ-
induced epileptic activity in mice
Epilepsy requires alternative non-invasive therapeutic strategies with reliable neuromodulatory effects.
This study presents a focused ultrasound stimulation (FUS) approach targeting the transcutaneous
auricular vagus nerve (taVNS) and evaluates its efficacy using a PTZ-induced seizure model with real-
time EEG monitoring. As shown in the figure, FUS was applied to the auricular region of mice (A–B),
and the acoustic field was characterized to confirm spatial pressure distribution at the focal zone (C). A
structured experimental timeline was implemented, including baseline (Normal) recording, PTZ-induced
seizure, ultrasound stimulation, and post-stimulation observation (D). EEG signals were continuously
recorded to assess neural activity changes. In the PTZ_only condition (E–F), seizure induction led to a
marked increase in epileptiform activity compared to baseline, reflected by elevated spike density and
total spike number. Quantitative analysis demonstrated a significant rise in spike numbers following PTZ
administration, which remained elevated during the sham ultrasound phases, indicating sustained epileptic
activity without intervention. In contrast, ultrasound-treated animals (G–H) exhibited a clear reduction in
epileptiform discharges during stimulation and a further decrease in the post-stimulation phase. Spike
number significantly decreased compared to the PTZ condition, demonstrating effective suppression of
seizure activity. The reduction persisted after stimulation, suggesting a sustained neuromodulatory effect.
Overall, these results demonstrate that FUS-mediated taVNS can effectively attenuate PTZ-induced
epileptic activity by reducing spike frequency and overall spike burden. This non-invasive approach shows
strong potential for developing ultrasound-based neuromodulation therapies for epilepsy.